Impacts of acquisition and reconstruction parameters on the absolute technetium quantification of the cadmium–zinc–telluride-based SPECT/CT system: a phantom study

Abstract Background The digital cadmium–zinc–telluride (CZT)-based SPECT system has many advantages, including better spatial and energy resolution. However, the impacts of different acquisition reconstruction parameters on CZT quantification might still need to be validated. This study aimed evaluate (the main window time per frame) number iterations, subsets in iterative reconstruction, post-filter, image correction methods) technetium SPECT/CT. Methods A phantom (PET NEMA/IEC quality, USA) was filled with four target-to-background (T/B) ratios (32:1, 16:1, 8:1, 4:1) technetium. Mean uptake values calculated mean concentrations for spheres) were measured recovery coefficient (RC) changes under parameters. corresponding standard deviations also error. Image quality evaluated using National Electrical Manufacturers Association (NEMA) NU 2–2012 standard. Results For all T/B ratios, significant correlations found between iterations RCs ( r = 0.62–0.96 1–35 0.94–0.99 35–90 iterations) as well full width at half maximum (FWHM) Gaussian filter − 0.86 1.00, P < 0.05). regression coefficients higher than those (0.51–1.60 vs. 0.02–0.19). AC (attenuation correction) + SC (scatter RR (resolution combination more accurate (53.82–106.70%) other combinations (all No statistical differences > 0.05) 15% 20% windows except 32:1 ratio value 0.023) or 10 s/frame 120 times 4:1 0.015) terms RCs. Conclusions CZT-SPECT/CT resulted good accuracy. favourable a 40 time. 35 20 subsets, combination, no filter.